| Pfander D, Kobayashi T, Knight, M. C., Zelzer E, Chan, D. A., Olsen, B. R., Giaccia, A. J., Johnson, R.S., Haase, V. H., Schipani E (2004). Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development 131(10):2497-508. |
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| Bemis L, Chan, D.A., Finkielstein, C. V., Qi L, Sutphin, P. D., Chen X, Stenmark K, Giaccia, A. J., Zundel W (2004). Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5. Genes Dev 18(7):739-44. |
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| Swiersz, L. M., Giaccia AJ, Yun Z. (2004). Oxygen-dependent regulation of adipogenesis. Methods Enzymol 381:387-95. |
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| Park, S., Dadak, A.M., Haase, V.H., Fontana, L., Giaccia, A.J. and Johnson, R.S. Hypoxia-induced gene expression occurs solely through the action of Hypoxia-Inducible Factor (HIF)-1: the role of cytoplasmic trapping of HIF-2. Mol Cell Biol 23:4959-4971, 2003. |
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| Park, S., Dadak, A.M., Haase, V.H., Fontana, L., Giaccia, A.J. and Johnson, R.S. Hypoxia-induced gene expression occurs solely through the action of Hypoxia-Inducible Factor (HIF)-1: the role of cytoplasmic trapping of HIF-2. Mol Cell Biol 23:4959-4971, 2003. |
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| Hammond, E.M., Dorie, M.J. and Giaccia, A.J. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to re-oxygenation. J Biol Chem 278:12207-12213, 2003. |
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| Le, Q.-T. , Sutphin, P.D., Raychaudhuri, S., Yu, S.C., Terris, D.J., Lin, H.S., Lum, B., Pinto, H.A., Koong, A.C. and Giaccia, A.J. Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas. Clin Cancer Res 9:59-67: 2003. |
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| Chan, D.A., Sutphin, P.D., Denko, N.C. and Giaccia, A.J. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1a. J Biol Chem 277:40112-40117, 2002. |
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| Hudson, C.C., Liu, M., Kaper, F., Chiang, G., Otterness, D., Giaccia, A.J. and Abraham, R.T. Regulation of hypoxia-inducible factor-1a expression and function by the mammalian target of rapamycin. Mol Cell Biol 22:7004-7014, 2002. |
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| Maecker, H.L, Yun, Z., Maecker, H.T. and Giaccia, A.J. Epigenetic Changes in Tumor Fas Levels Determine Immune Escape and Response to Therapy. Cancer Cell 2:139-148, 2002. |
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| Lluria-Prevatt, M., Morreale, J., Gregus, J., Alberts, D.S., Kaper, F., Giaccia, A. and Powell, M.B. Effects of perillyl alcohol on melanoma in the TPras mouse model. Cancer Epidemiol Biomarkers Prev.11:573-579, 2002. |
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| Shibata, T., Giaccia, A.J. and Brown, J.M. Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy. Neoplasia 4:40-48, 2002. |
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| Liu, S.C., Minton, N.P., Giaccia, A.J. and Brown, J.M. Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis. Gene Ther 9:291-296, 2002. |
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| Yun, Z., Maecker, H.L, Johnson, R.S. and Giaccia, A.J. Inhibition of PPARg2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell 2:331-341, 2002. |
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| Popovici, R.M., Lu, M., Bhatia, S., Faessen, G.H, Giaccia, A.J. and Giudice, L.C. Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency. J Clin Endocrinol Metab 86:2653-2659, 2001. |
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| Chen, E.Y., Mazure, N.M., Cooper, J.A and Giaccia A.J. Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation. Cancer Res 61:2429-2433, 2001. |
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| Denko, N.C. and Giaccia, A.J. Tumor hypoxia, the physiological link between Trousseau’s Syndrome (carcinoma-induced coagulopathy) and metastasis? Cancer Res 61:795-798, 2001. |
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| Koumenis C., Alarcon, R., Hammond, E., Sutphin, P., Hoffman, W., Murphy, M., Derr, J., Taya, Y., Kastan, M. and Giaccia, A.J. Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol Cell Biol 21:1297-1310, 2001. |
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| Green, S., Freiberg, R.A. and Giaccia, A.J. p21Cip1 and p27Kip1 regulate cell cycle re-entry after hypoxic stress but are not necessary for hypoxia-induced arrest. Mol Cell Biol 21:1196-1206, 2001. |
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| Maecker, H.L. Koumenis, C. and Giaccia, A.J. p53 promotes selection for Fas-mediated apoptotic resistance. Cancer Res 60:4638-4644, 2000. |
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| Shibata, T., Giaccia, A.J. and Brown, J.M. Development of a hypoxia-responsive vector for tumor-specific gene therapy. Gene Ther 7:493-498, 2000. |
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| Denko, N., Schindler, C., Koong, A., Laderoute, K., Green, C. and Giaccia, A.J. Epigenetic Regulation of Gene Expression in Cervical Cancer Cells by the Tumor Microenvironment. Clin Cancer Res 6:480-487, 2000. |
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| Koong, A.C., Denko, N.C., Schindler, C., Swiersz, L., Le, Q.T., Koch, C., Evans, S. and Giaccia, A.J. Candidate genes for the hypoxic tumor phenotype. Cancer Res 60:883-887, 2000. |
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| Zundel, W., Swiersz, L.M. and Giaccia, A.J. Caveolin-1 mediated regulation of receptor tyrosine kinase-associated PI(3)K activity by ceramide. Mol Cell Biol 20:1507-1514, 2000. |
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| Zundel, W., Schindler, C., Haas-Kogan, D., Koong, A., Kaper, F., Chen, E., Shalev, N., Ryan, H.E., Johnson, R.S., Jefferson, A.B., Stokoe, D. and Giaccia, A.J. Loss of PTEN facilitates HIF-1 mediated gene expression. Genes Dev 14:391-396, 2000. |
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| Alarcon, R. Koumenis, C., Geyer, R.K., Maki, C.G. and Giaccia, A.J. Hypoxia induces p53 accumulation through MDM2 downregulation and inhibition of E6 mediated degradation. Can Res 59:6046-6051, 1999. |
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| Chen, E.Y., Fujinaga, M. and Giaccia, A.J. The hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development. Teratology 60: 215-225, 1999. |
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| Laderoute, K.R., Mendonca, H.L., Calaoagan, J.M., Knapp, A.M., Giaccia, A.J. and Stork, P.J.S. Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate mkp for the inactivation of hypoxia-inducible stress-activated protein kinase/c-jun N-terminal protein kinase activity. J Biol Chem 274:12890-7, 1999. |
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| Soengas, M.S., Alarcon, R.M., Yoshida, H., Giaccia, A.J., Hakem, R., Mak, T.W. and Lowe, S.W. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 284:156-159, 1999. |
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| Murphy, B.J., Andrews, G.K., Bittel, D., Discher, D.J., McCue, J., Green, C.J., Yanovsky, M., Giaccia, A., Sutherland, R.M., Laderoute, K.R., Webster, K.A. Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1. Cancer Res 59:1315-1322, 1999. |
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| Zundel, W. and Giaccia, A.J. Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress. Genes Dev 12:1941-1946, 1998. |
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| Koumenis, C. and Giaccia, A.J. Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis. Mol Cell Biol 17:7306-7316, 1997. |
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| Mazure, N.M., Chen, E.Y., Laderoute, K.R. and Giaccia, A.J. Induction of vascular endothelial growth factor by hypoxia is modulated by a PI 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a HIF-1 transcriptional element. Blood 90:3322-3331, 1997. |
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| Graber, T.G., Osmanian, C., Jacks, T., Housman, D.E., Koch, C.J., Lowe, S.W., Giaccia, A.J. Hypoxia-mediated selection of cells with diminshed apoptotic potential in solid tumours. Nature 379: 88-91, 1996. |
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